The Analgesic Metamizol (Dipyrone). Part 2: Adsorption, Oxidative and Reductive Degradation
نویسندگان
چکیده
منابع مشابه
The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives.
BACKGROUND AND PURPOSE Although still used by hundreds of millions of people worldwide, the mechanism of the analgesic action of the pyrazolone derivatives (PDs), dipyrone, propyphenazone and antipyrine remains unknown. The transient receptor potential ankyrin 1 (TRPA1) channel, expressed by nociceptors, is emerging as a major pain transduction pathway. We hypothesized that PDs target the TRPA1...
متن کاملOxidative Degradation of 2-chlorophenol by Persulfate
The degradation of 2-chlorophenol (2-CP) by persulfate was investigated. The kinetics of persulfate oxidation of 2-chlorophenol in aqueous solutions at various pH, oxidant concentration, temperature, Fe2+ and Cu2+ ions content was studied. Maximum of 2-CP degradation occurred at pH 8. The oxidation rate of 2-CP increased with increasing the persulfate molar excess. The degradation process was s...
متن کاملOxidative and Reductive Enzymes: Phase I Reactions
Both metabolism and excretion can be viewed as processes responsible for elimination of drug (parent and metabolite) from the body. Drug metabolism changes the chemical structure of a drug to produce a drug metabolite, which is frequently but not universally less pharmacologically active. Metabolism also renders the drug compound more water soluble and therefore more easily excreted. Drug metab...
متن کاملUranium-mediated oxidative addition and reductive elimination.
Oxidative addition, and its reverse reaction reductive elimination, constitute two key reactions that underpin organometallic chemistry and catalysis. Although these reactions have been known for decades in main group and transition metal systems, they are exceptionally rare or unknown for the f-block. However, in recent years much progress has been made. In this Perspective article, advances i...
متن کاملOxidative degradation of silica-supported polyethylenimine for CO2 adsorption: insights into the nature of deactivated species.
The oxidative degradation of polyethylenimine-impregnated mesoporous SBA-15 silica for CO2 capture was investigated at the molecular level. The adsorbents were exposed to flowing air at different temperatures, and their degree of deactivation was evaluated through the measurement of CO2 adsorption capacity prior and subsequent to air exposure. A solvent-extraction method was employed to isolate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: World Journal of Chemical Education
سال: 2018
ISSN: 2375-1665
DOI: 10.12691/wjce-6-5-1